Cancer Therapy: Preclinical BRaf andMEK Inhibitors Differentially Regulate Cell Fate and Microenvironment in Human Hepatocellular Carcinoma
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چکیده
Purpose: Small molecule inhibitors of the mitogen-activated protein kinase (MAPK) pathway, such as sorafenib, represent novel treatment options for advanced hepatocellular carcinoma. The aim of our study was to identify downstream targets as biomarker candidates that are directly linked to the oncogenic MAPK pathway in hepatocellular carcinoma and correlate with inhibition of this pathway by multikinase
منابع مشابه
BRaf and MEK inhibitors differentially regulate cell fate and microenvironment in human hepatocellular carcinoma.
PURPOSE Small molecule inhibitors of the mitogen-activated protein kinase (MAPK) pathway, such as sorafenib, represent novel treatment options for advanced hepatocellular carcinoma. The aim of our study was to identify downstream targets as biomarker candidates that are directly linked to the oncogenic MAPK pathway in hepatocellular carcinoma and correlate with inhibition of this pathway by mul...
متن کاملBRaf and MEK inhibitors differentially regulate cell fate and microenvironment in human hepatocellular carcinoma Running title: MAPK inhibition, signaling and microenvironment in HCC
Purpose: Small molecule inhibitors of the mitogen activated protein kinase (MAPK) pathway like sorafenib represent novel treatment options for advanced hepatocellular carcinoma (HCC). The aim of our study was to identify downstream targets as biomarker candidates that are directly linked to the oncogenic MAPK pathway in HCC and correlate with inhibition of this pathway by multi-kinase inhibitor...
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Human hepatocellular carcinoma is one of the most common recurrent malignancies, for as much as, there is no effective therapy. Silibinin, a widely used drug and supplement for various liver disorders, demonstrated anticancer effects against human hepatocellular carcinoma, human prostate adenocarcinoma cells, human breast carcinoma cells, human ectocervical carcinoma cells, and human colon canc...
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تاریخ انتشار 2014